‘Michael’ in Daniel 12:1, then, is Christ. It is Jesus at the time of His incarnation, crucifixion, and resurrection. Thus, both Luther and Calvin. Then, within the very same generation of His incarnation, much would happen.
That, said Daniel, "shall be a time of trouble such as never was, since there was a nation, even to that same time." According to Jesus Himself, this refers especially to the time from the middle of A.D. 66 until 70 — during the Roman siege of Jerusalem. Daniel 12:1b. See too: Matthew 23:29-38 & 24:1,2,15,21,34.
Next, in Daniel 12:4, the prophet was instructed to "shut up the words and seal the book" — until that "time of trouble." Earlier, in Daniel 9:24-27, it had already been predicted that the ‘canon’ of Holy Scripture would be completed around that very time.
There, predicted the inspired Daniel: "Seventy weeks-of-years have been determined…, to seal up the vision and prophecy…. Then the people of the [Roman] prince that shall come, shall destroy the city and the sanctuary" — in 70 A.D!
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Probably from even before, and certainly from not long after 70 A.D., Britain in particular and much of Europe in general started becoming Christian alias Proto-Protestant. Then, especially around the fifth century A.D., the Roman Empire broke up into ten "horns" or kingdoms — followed by another diverse and blasphemous "horn." Daniel 2:41f; 7:7,20,25; Revelation 13:1-18; 17:3-16.
From around A.D. 600 onward, only the bishop at Rome was called ‘pope’ (alias ‘ father’ or, very euphemistically, ‘holy father’). The first papal missionary to Britain, the 600f Austin of Rome, was then stoutly resisted by the Culdee or Proto-Protestant British Celtic Christians.
Only after the 664 Synod of Whitby, from about A.D. 666 onward did most of Europe and some of England — but not (till very much later) Ireland, Scotland or Wales — become increasingly romanized. Thus, the Romish papal power or "horn" became strong or "stout" — and long sat and ruled in the Church alias the temple of God, claiming to be His spokesman.
However, that spokesman was in fact ‘the man of sin’ — alias Antichrist. Such was the one who first claimed to speak on behalf of Christ; the one who later claimed to speak in the place or stead of Christ; and who subsequently spoke instead of and sometimes even against the Christ of Scripture. Daniel 7:25; 8:20-25; 11:36f; 12:8-11; Second Thessalonians 2:3-12; Second Peter 2:1-5f; Revelation 13:11-18; 17:1-17.
Such Roman-Romish impiety would thereafter long continue. It would desecrate the sanctuary alias the Christian Church, and then itself linger on for many centuries. Indeed, even as late as A.D. 1561 — Calvin commented on Daniel 12:4: "At the present time, in the Papacy…, impiety prevails."
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In Daniel 12:5-6, we read that the prophet Daniel heard an angel ask the pre-incarnate Christ: "How long shall it be to the end of these wonders?" That is — how long would it be, after 70 A.D., before the predictions contained in these Holy Scriptures would be fulfilled? Cf. Daniel 7:19-25 and 8:9-14 with 12:7-12.
In Daniel 12:7, we learn that the pre-incarnate Christ then replied. It would be — He Himself said — "for a time, two times, and an half." See too: Revelation 11:2f; 12:6f; 13:5f.
Now "here" in Daniel 12:7-11, comments Calvin, "‘time’ means a long period; ‘times’ a longer period; and ‘a half’ means the end or closing period. The sum of the whole, is this: many years must elapse, before God fulfils what His prophet had declared!"